Human tumor necrosis factor is a chemoattractant for the parasite Entamoeba histolytica.
نویسندگان
چکیده
In an analysis of the molecular factors triggering amebiasis, we investigated the chemotaxis of Entamoeba histolytica toward tumor necrosis factor (TNF) in vitro, using quantitative imaging techniques. Our findings enabled us to propose a hitherto unknown role for TNF as a chemokinetic and chemoattractant agent for this parasite.
منابع مشابه
In Entamoeba histolytica, a BspA family protein is required for chemotaxis toward tumour necrosis factor
BACKGROUND Entamoeba histolytica cell migration is essential for the development of human amoebiasis (an infectious disease characterized by tissue invasion and destruction). The tissue inflammation associated with tumour necrosis factor (TNF) secretion by host cells is a well-documented feature of amoebiasis. Tumour necrosis factor is a chemoattractant for E. histolytica, and the parasite may ...
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Entamoeba histolytica is a protozoan parasite, and is the causal agent of human amebiasis whose primary mode of transmission is the ingestion of food and/or water that is contaminated with feces containing E. histolytica cysts. Excystation is the stage in a parasite's life cycle, which occurs after the cystic form has been swallowed by the host. When excystation occurs in the intestinal lumen, ...
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عنوان ژورنال:
- Infection and immunity
دوره 74 2 شماره
صفحات -
تاریخ انتشار 2006